| Elimination: elimination half-life loperamide in humans is about 11 hours with a range of 9-14 hours. Excretion of unchanged loperamide and its metabolites occurs mainly in the faeces.
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The population of pediatric patients: a population pharmacokinetic studies pediatric patients have not performed. It is expected that the pharmacokinetic behavior of loperamide and interactions of drugs with loperamide are similar to those observed in adults.
Indication
Symptomatic treatment of acute diarrhea in adults and children aged 12 years.
Symptomatic treatment of acute episodes of diarrhea caused by irritable bowel syndrome in adults 18 years after initial diagnosis by a doctor.
Contraindication
Imodium® contraindicated:
patients with a known hypersensitivity to loperamide hydrochloride or to any component of the drug;
children under 12 years;
patients with acute dysentery, characterized by blood in stools and high fever;
patients with acute ulcerative colitis or pseudomembranous colitis associated with the use of broad-spectrum antibiotics;
patients with bacterial enterocolitis caused by germs family Salmonella, Shigella and Campylobacter.
Imodium® not to be used if necessary to avoid inhibition of peristalsis because of possible risk of significant complications including intestinal obstruction, megacolon and toxic megacolon.
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It should immediately stop taking the drug, if developed constipation, bloating or intestinal obstruction.
Interaction with other medicinal products and other forms of interaction
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Cases of interactions with drugs with similar pharmacological properties. Drugs with inhibitory effects on the central nervous system is not used in conjunction with taking Imodiumu® children.
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