| Clarithromycin price
Strong inducers isozymes of cytochrome P450, such as efavirenz, nevirapine, rifampicin, rifabutin and rifapentine able to accelerate clarithromycin metabolism and thus lower the concentration of clarithromycin in plasma and reduce its therapeutic effect and at the same time increase the concentration of 14-OH-clarithromycin - metabolite, which is also microbiologically active. Since the microbiological activity of clarithromycin and 14-OH varies clarithromycin against various bacteria, the therapeutic effect may be reduced when used in conjunction clarithromycin and enzyme inducers.
Clarithromycin price
The concentration of clarithromycin in plasma decreases with use etravirine, it increases the concentration of the active metabolite 14-OH clarithromycin. Since the 14-OH-clarithromycin has low activity against infections MAC, may change the overall activity against their pathogens, so alternative treatment should be considered for treating MAC.
Pharmacokinetic study showed that co-administration of ritonavir 200 mg every 8 hours and clarithromycin, 500 mg every 12 hours resulted in a marked suppression of metabolism of clarithromycin. When co-administered clarithromycin Cmax of ritonavir increased by 31%, Cmin increased by 182% and AUC increased by 77%, while the concentration of its metabolite 14-OH clarithromycin significantly decreased. Ritonavir should not be taken together with clarithromycin at doses greater than 1 g / day.
Clarithromycin price
Clarithromycin, atazanavir, saquinavir are substrates and inhibitors of CYP3A, which determines their bidirectional interaction. When taken together with ritonavir, saquinavir should take into account the potential impact of ritonavir on clarithromy
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