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In a joint application of clarithromycin and triazolam possible effects on the central nervous system, such as drowsiness and confusion. When this combination is recommended to control the symptoms of CNS disorders follow.
In an application with warfarin may increase the anticoagulant action of warfarin and increase the risk of bleeding.
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It is assumed that digoxin is a substrate for P-glycoprotein. It is known that clarithromycin inhibits P-glycoprotein. In an application with digoxin possible a significant increase in the concentration of digoxin in the blood plasma and the risk of glycoside intoxication.
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Perhaps the emergence of ventricular tachycardia type "pirouette" in the combined use of clarithromycin and quinidine or disopyramide. At simultaneous reception of clarithromycin with these drugs should be regularly tested for ECG increase the interval QT, and should monitor serum concentrations of these drugs. In postmarketing use of reported cases of hypoglycemia during coadministration of clarithromycin and disopyramide. It is necessary to monitor the concentration of glucose in the blood, while the application of clarithromycin and disopyramide. It is believed that disopyramide may increase plasma concentrations due to the inhibition of its metabolism in the liver under the influence of clarithromycin.
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| Категория: drug clarithromycin | Добавил: Dnister (22.11.2016)
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