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Joint administration of fluconazole 200 mg daily and clarithromycin 500 mg 2 times / day caused an increase in the average value of the equilibrium concentration of clarithromycin minimum (Cmin), and AUC by 33% and 18% respectively. In this co-administration does not significantly affect the average equilibrium concentration of the active metabolite 14-OH clarithromycin. Adjusting the dose of clarithromycin when receiving concomitant fluconazole is required.
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Clarithromycin and itraconazole are substrates and inhibitors of CYP3A, which determines their bidirectional interaction. Clarithromycin can increase itraconazole concentration in the plasma, while itraconazole can increase the plasma concentration of clarithromycin.
While the use of methylprednisolone - methylprednisolone clearance decreases; prednisone - described cases of acute mania and psychosis.
In an application with omeprazole significantly increases the concentration of omeprazole and clarithromycin significantly increased the concentration in the blood plasma; with lansoprazole - possible glossitis, stomatitis and / or the appearance of dark color language.
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In an application with sertraline - theoretically impossible to exclude the development of serotonin syndrome; theophylline - possibly increasing theophylline concentration in plasma.
When applied simultaneously with terfenadine possible slowing of the metabolism of terfenadine and increase its concentration in blood plasma, which may lead to an increase in QT interval and an increased risk of ventricular arrhythmias such as "pirouette".
Inhibition of CYP3A4 activity under the influence of clarithromycin slows down the rate of metabolism of cisapride in their simultaneous application.
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