| Biaxin xl pack
The same pattern was observed while taking astemizole with drugs macrolide.
There are reports on the development of torsades de pointes ventricular, while the use of clarithromycin and quinidine, and disopyramide. When concomitant administration of these drugs require monitoring of their concentration in the blood. With simultaneous use of clarithromycin with digoxin observed elevated levels of digoxin in serum. Such patients need to monitor the content of digoxin in serum.
With simultaneous use of theophylline and carbamazepine with clarithromycin observed a moderate but significant (p <0.05) increase in the content of theophylline and carbamazepine in plasma.
At the same time taking clarithromycin inhibitors hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors (such as lovastatin and simvastatin) described rare cases of rhabdomyolysis.
Biaxin xl pack
Colchicine is a substrate of CYP3A and Pgp. Clarithromycin and other macrolides are inhibitors of CYP3A and P-glycoprotein. When coadministered colchicine and clarithromycin, inhibition of 3-glycoprotein and / or CYP3A can lead to increased action of colchicine. Patients should be carefully monitored in order to identify the symptoms of the toxic effect of colchicine.
Simultaneous oral administration of clarithromycin and zidovudine in HIV-infected patients had a decrease in the equilibrium concentration of zidovudine. Because clarithromycin affects the absorption of zidovudine, taking these two drugs should be separated in time.
Biaxin xl pack
Ritonavir significantly slows clarithromycin metabolism while receiving. The value of Cmax of clarithromycin increased by 31%, the minimum concentration (Cmin) - by 182%, the area under the curve "concentration-time" - 77%. There has been a significant slowdown in the process of formation of a 14-hydroxyclarithromycin. In this case, in patients without renal dysfunction is not necessary to adjust the dose of clarithromycin. When receiving ritonavir should not be administered dosage of clarithromycin at the same time more than 1 g per day.
Perhaps the development of cross-resistance between the clarithromycin and other drugs macrolide such as lincomycin and clindamycin. With simultaneous use of clarithromycin and hypoglycemic agents, including insulin, in rare cases may develop hypoglycaemia.
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