| Biaxin and clarithromycin
Allergic reactions: skin redness, hives, skin rash, angioedema, bronchospasm, eosinophilia; rarely - anaphylactic shock, Stevens-Johnson syndrome.
Other: fever, may develop superinfection, candidiasis, the development of resistance of microorganisms.
Overdose
Symptoms: The symptoms of the gastrointestinal tract; one patient with bipolar disorder history after taking 8 grams of clarithromycin described impaired mental status, paranoid behavior, hypoglycemia, hypoxemia.
Treatment: gastric lavage, symptomatic therapy.
There is no specific antidote.
Interaction with other drugs
Biaxin and clarithromycin
Clarithromycin is not administered with cisapride, pimozide, terfenadine.
Simultaneous administration of clarithromycin with drugs metabolized by the cytochrome P450 can lead to an increase in the concentration of drugs in blood plasma as triazolam, astemizole, carbamazepine, cilostazol, cisapride, cyclosporin, disopyramide, ergot alkaloids, lovastatin, methylprednisolone, midazolam, omeprazole, oral anticoagulants (such as warfarin), pimozide, quinidine, rifabutin, sildenafil, simvastatin, tacrolimus, terfenadine, triazolam, vinblastine, phenytoin, theophylline and valproate.
Biaxin and clarithromycin
With simultaneous use of clarithromycin with cisapride was observed increase in the concentration of cisapride. This may cause an increase in the interval QT, arrhythmia, ventricular tachycardia, fibrillation and torsades de pointes ventricular. Similar effects have been observed in patients taking clarithromycin concurrently with pimozide.
macrolide drugs affect the metabolism of terfenadine. The level of terfenadine in the blood increases, which may be accompanied by the development of arrhythmias, increase the interval QT, ventricular tachycardia, atrial fibrillation, and atrial flutter, ventricular fibrillation. The content of the acid metabolite of terfenadine increased by 2-3 times, QT interval is increased, however, it does not cause any clinical symptoms.
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