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Drug interaction Not recommended concomitant use of ibuprofen with aspirin and other NSAIDs. When concomitant administration of ibuprofen reduces inflammatory and antiplatelet effect of acetylsalicylic acid (may increase the incidence of acute coronary insufficiency in patients receiving antiplatelet agents as low-dose acetylsalicylic acid, after you start taking ibuprofen). In the appointment of anticoagulant and thrombolytic drugs (alteplase, streptokinase, urokinase) also increase the risk of bleeding. Simultaneous treatment with serotonin reuptake inhibitors (citalopram, fluoxetine, paroxetine, sertraline) increases the risk of serious gastrointestinal bleeding. Tsefamandol, tsefaperazon, tsefotetan, valproic acid, plikamitsin, increase the incidence of gipoprotrombinemii. Cyclosporine and gold preparations boost the effect of ibuprofen on prostaglandin synthesis in the kidneys, which is manifested by increased nephrotoxicity.
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Ibuprofen increases the plasma concentration of cyclosporin and the likelihood of its hepatotoxic effects. Drugs that block tubular secretion, reduce excretion and increase plasma concentration of ibuprofen. Inductors microsomal oxidation (phenytoin, ethanol (alcohol), barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of severe intoxication. Inhibitors of microsomal oxidation - reduce the risk of hepatotoxicity. Reduces hypotensive activity of vasodilator, diuretic and natriuretic activity in furosemide and hydrochlorothiazide. Reduces the effectiveness of uricosuric drugs, increases the effects of anticoagulants, antiplatelet agents, fibrinolytic agents (increasing the risk of bleeding disorders), enhances the ulcerogenic effect of bleeding mineralokortikosteroidov, corticosteroids, colchicine, estrogens, ethanol (alcohol). Do effect of oral hypoglycemic drugs and insulin, sulfonylureas.
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Antacids and cholestyramine reduce the absorption. Increases concentration of digoxin in the blood, drugs lithium methotrexate. Caffeine increases the analges
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